The Short Version
Debt-to-income (DTI) is the second-most-decisive factor in mortgage approval after credit. It's the percentage of your gross monthly income that goes to debt payments - including the new mortgage. Lenders look at it two ways: front-end (just housing) and back-end (housing plus every other minimum payment).
Most programs cap back-end DTI in the 45%–50% range, with room to stretch on FHA and with strong compensating factors. If you're near the cap, small moves - paying off a small card, restructuring a car loan - can be the difference between approved and declined.
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